Thyrotoxic Periodic Paralysis- A Clinical Review

Thyrotoxic Periodic Paralysis: Clinical Challenges

Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis. Factors like high-carbohydrate meal exercise, steroid, and stress can precipi...

Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge.

CONTEXT The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP). EVIDENCE ACQUISITION A MEDLINE search was conducted for articles published during the last 40 yr based on the key words thyrotoxic periodic paralysis and hypokalemic periodic paralysis. A total of 281 primary articles and 168 references of the retrieved...

Thyrotoxic Periodic Paralysis – Clinical Diagnosis and Management

Thyrotoxic periodic paralysis: clinical and molecular aspects.

Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism that most often affects young East Asian males but increasingly also in other ethnic groups. The typical presentation is acute attacks varying from mild weakness to total paralysis starting at night or in the early morning a few hours after a heavy meal, alcohol abuse or strenuous exercise with complete recovery withi...

Thyrotoxic periodic paralysis.

Periodic flaccid paralysis of skeletal muscle occurring in a thyrotoxic patient, an unusual and dramatic event, is seen predominantly in Oriental men. It is important to remember the clinical association between periodic paralysis and thyrotoxicosis.